List your practice on InjuredCare | Log in / Sign up

Onglyza

Onglyza

Onglyza was co-formulated by Bristol-Myers Squibb and AstraZeneca in 2007. On July 31, 2009, it was approved by the FDA for treatment of type-2 diabetes. Its key active ingredient, saxagliptin, is a DPP-4 (dipeptidyl peptidase-4) inhibitor. This means it works to prohibit the DPP-4 enzyme from performing its normal function of destroying incretin, which is the hormone responsible for producing insulin and eliminating excess glucose production.

Negative side effects of Onglyza

On April 5, 2016, the FDA issued a warning for type-2 diabetes medications that contain saxagliptin. This safety announcement stated that medications containing saxagliptin lead to an increased risk of heart failure, especially for patients with a history of heart or kidney illnesses. Diabetes medications like Onglyza, which contain saxagliptin, were required to add this warning to their label.

Severe side effects of Onglyza (other than heart failure) can include the following:

  • Low blood sugar
  • Pancreatitis - inflammation of the pancreas
  • Joint pain
  • A rare skin condition (bullous pemphigoid) that causes severe blisters
  • Peripheral edema - fluid retention that leads to swelling of hands, feet, or ankles

Bristol-Myers Squibb and AstraZeneca face over 100 product liability lawsuits

Before Onglyza carried proper warnings on its label, many patients were unknowingly exposed to an increased risk of heart failure. This has led to lawsuits against co-manufacturers Bristol-Myers Squibb and AstraZeneca. Around 100 individual lawsuits from throughout the United States have been consolidated in federal multi-district litigation in the United States District Court for the Eastern District of Kentucky. Other lawsuits also pending in California.

Related Articles

  • Neurontin

    Neurontin

    The Trade Name for the Prescription Anticonvulsant Gabapentin Gabapentin, now marketed under the product name Neurontin, was first developed in 1975 by Parke-Davis, now a subsidia Read More...

  • Tequin

    Tequin

    Tequin is part of the family of antibiotics used to treat select bacterial infections. It was prepared in oral tablets, injections, and oral suspensions to treat infections occurri Read More...

  • Ischemic and Hemorrhagic Strokes

    Ischemic and Hemorrhagic Strokes

    A stroke is a medical condition caused by the cessation or diminishment of the flow of blood to the brain, which causes brain cells to die. Strokes are categorized as either ischem Read More...

© 2015-2022 LawConnect, Inc. All rights reserved.

CONCEPT, DESIGN and HOSTING BY GETLEGAL.COM’S WEB SERVICES TEAM..